Hydrophobic benzoic acids as inhibitors of influenza neuraminidase

Hydrophobic benzoic acids as inhibitors of influenza neuraminidase

Source :

• Bioorganic & Medicinal Chemistry [ 0968-0896 ] ; 1999.

Descripteurs français

• KwdFr :
  • Antienzymes (pharmacologie), Antienzymes (synthèse chimique), Antiviraux (pharmacologie), Antiviraux (synthèse chimique), Benzoates (), Benzoates (pharmacologie), Benzoates (synthèse chimique), Conformation des protéines, Cristallographie aux rayons X, Modèles moléculaires, Orthomyxoviridae (), Orthomyxoviridae (enzymologie), Sialidase (), Sialidase (antagonistes et inhibiteurs).
• MESH :
  • antagonistes et inhibiteurs : Sialidase.
  • enzymologie : Orthomyxoviridae.
  • pharmacologie : Antienzymes, Antiviraux, Benzoates.
  • synthèse chimique : Antienzymes, Antiviraux, Benzoates.
• Pascal (Inist)
  • Acide carboxylique, Antiviral, Benzoates, Benzoïque acide(4-acétamido-3-[1-éthylpropoxy]-5-guanidino), Carboxamide, Complexe enzyme inhibiteur, Composé benzénique, Conformation des protéines, Cristallographie aux rayons X, Exo-α-sialidase, Guanidines, Influenzavirus A, Inhibiteur enzyme, Interaction hydrophobe, Modèle moléculaire, Modèles moléculaires, Modélisation, Orthomyxoviridae, Relation structure activité, Sialidase, Site fixation, Synthèse chimique, Sélectivité.

English descriptors

• KwdEn :
  • Antiviral, Antiviral Agents (chemical synthesis), Antiviral Agents (pharmacology), Benzenic compound, Benzoates (chemical synthesis), Benzoates (chemistry), Benzoates (pharmacology), Binding site, Carboxamide, Carboxylic acid, Chemical synthesis, Crystallography, X-Ray, Enzyme Inhibitors (chemical synthesis), Enzyme Inhibitors (pharmacology), Enzyme inhibitor, Exo-α-sialidase, Guanidines, Hydrophobic interaction, Influenzavirus A, Inhibitor enzyme complex, Modeling, Models, Molecular, Molecular model, Neuraminidase (antagonists & inhibitors), Neuraminidase (chemistry), Orthomyxoviridae (drug effects), Orthomyxoviridae (enzymology), Protein Conformation, Selectivity, Structure activity relation.
• MESH :
  • chemical , antagonists & inhibitors : Neuraminidase.
  • chemical , chemical synthesis : Antiviral Agents, Benzoates, Enzyme Inhibitors.
  • chemical , chemistry : Benzoates, Neuraminidase.
  • chemical , pharmacology : Antiviral Agents, Benzoates, Enzyme Inhibitors.
  • drug effects : Orthomyxoviridae.
  • enzymology : Orthomyxoviridae.
  • Crystallography, X-Ray, Models, Molecular, Protein Conformation.
• Teeft :
  • Acetic, Acetic anhydride, Active site, Anal, Anhydride, Aqueous layer, Aqueous layers, Atigadda, Bana, Benzoic, Benzoic acids, Binding site region, Bioorg, Calcd, Cdcl3, Chem, Cold water, Crystal structure, Dark reaction mixture, Dmso, Ether, Ethyl acetate, Glacial acetic acid, Glycerol binding subsite, Guanidine, Guanidino, Guanidino group, Hydrophobic, Hydrophobic pocket, Inhibitor, Inhibitor complexes, Laver, Lipophilic side chain, Ltered, Methanol, Methyl, Mmol, Naoh, Neuraminidase, Organic layer, Organic layers, Reaction mixture, Room temperature, Sodium bicarbonate, Sodium sulfate, Subsite, Varghese.

Abstract

• https://api.istex.fr/ark:/67375/6H6-P0VR9Q8V-3/fulltext.pdf

Affiliations:

• Australie, États-Unis
• Alabama, Oklahoma

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